/*** reset reloaded ***/
html, body, div, span, applet, object, iframe,
h1, h2, h3, h4, h5, h6, p, blockquote, pre,
a, abbr, acronym, address, big, cite, code,
del, dfn, em, font, img, ins, kbd, q, s, sam,p
small, strike, strong, sub, sup, tt, var,
b, u, i, center,
dl, dt, dd, ol, ul, li,
fieldset, form, label, legend,
table, caption, tbody, tfoot, thead, tr, th, td {
	margin: 0;
	padding: 0;
	border: 0;
	outline: 0;
	font-size: 100%;
	vertical-align: baseline;
	background: transparent;
}
body {
	line-height: 1;
}
ol, ul {
	list-style: none;
}
/*** end reset reloaded ***/

body {
	background-color: #eeeeee;
	font-family: Verdana, Arial, Helvetica, sans-serif;
	color: #000;
}

/*** page containers ***/

div#wrap {
	width: 1020px;
	margin: 0 auto 20px;
}
div#header {
	background-color: #fff;
	padding: 30px 0 0px;
	border-top: solid 3px #1d2b7d;
}
div#header_left {
	float: left;
	width: 215px;
	margin: 5px 0 0 30px;
	padding-bottom: 10px;
}
div#header_right {
	background-color: #fff;
	margin: 10px 30px 0px 275px;
}
div#header_right img.shire_logo {
    float:right;
    width: 88px;
    border: none;
}
div#content_box {
	background-color: #fff;
	padding-bottom: 20px;
	border-bottom: solid 2px #d6d6d6;
}
div#col_left {
	float: left;
	width: 215px;
	margin: 0 0 30px 30px;
}
div#contact_box {
	border: solid 1px #d2d5e5;
	margin: 15px 0;
}
div#contact_box div.img_center {
	text-align: center;
	display: block;
	margin-top: 3px;
}
div.contact_box_top {
    padding: 10px 10px 0;
}
div.contact_box_middle {
    padding: 0 10px;
}
div.contact_box_btm {
    margin: 0 10px 10px;
}
div#content_main {
	margin: 0 30px 0px 275px;
}
div.clear {
	display: block;
	clear: both;
}
div.references p  {
	padding-top: 25px !important;
	color: #7f7f7f !important;
}
div#footer {
	padding: 0 0 30px;
	color: #7f7f7f;
}
	div#footer .contact{
		text-decoration:none;
	}

/*** links ***/

a:link, a:visited {
	color: #1d2b7d;
	text-decoration: underline;
}
a:hover, a:active {
	color: #1d2b7d;
	text-decoration: none;
	background-color: #f4f5fe;
}
#footer a:hover, #footer a:active {
    background: none;
}
ul#main_nav {
    padding:45px 0 2px;
}
ul#main_nav li a:link, ul#main_nav li a:visited {
	color: #1d2b7d;
	background-color: #fff;
	text-decoration: none;
	padding: 10px 10px 2px;
}
ul#main_nav li a:hover, ul#main_nav li a:active {
	color: #fff;
	text-decoration: none;
	padding: 10px 10px 2px;
}
ul#main_nav li#nav_home a:hover, ul#main_nav li#nav_home a:active {
    background: #fff url(../img/nav_tabs_03.png) no-repeat bottom center;
}
ul#main_nav li#nav_physicians a:hover, ul#main_nav li#nav_physicians a:active {
    background: #fff url(../img/nav_tabs_05.png) no-repeat bottom center;
}
ul#main_nav li#nav_patients a:hover, ul#main_nav li#nav_patients a:active {
    background: #fff url(../img/nav_tabs_07.png) no-repeat bottom center;
}
ul#main_nav li#nav_moreinfo a:hover, ul#main_nav li#nav_moreinfo a:active {
    background: #fff url(../img/nav_tabs_09.png) no-repeat bottom center;
}
ul#main_nav li#nav_studycenters a:hover, ul#main_nav li#nav_studycenters a:active {
    background: #fff url(../img/nav_tabs_09.png) no-repeat bottom center;
}
ul#main_nav li#nav_resources a:hover, ul#main_nav li#nav_resources a:active {
    background: #fff url(../img/nav_tabs_05.png) no-repeat bottom center;
}
ul#main_nav li#nav_replagal a:hover, 
ul#main_nav li#nav_replagal a:active {
    background: #fff url(../img/nav-treatment.gif) no-repeat bottom center;
}

div#contact_box a.arrow {
	display: block;
	background: transparent url(../img/arrow.png) no-repeat 0 65%;
	font-size: .85em;
	padding-left: 12px;
}
h1 a:link, h1 a:visited, h1 a:hover, h1 a:active {
    text-decoration: none;
    background: none;
}

/*** this page nav indicators ***/

#body_home li#nav_home a {
	color: #fff;
	background: #fff url(../img/nav_tabs_03.png) no-repeat bottom center;
	text-decoration: none;
	padding: 10px 10px 2px;
}
#body_physicians li#nav_physicians a {
	color: #fff;
	background: #fff url(../img/nav_tabs_05.png) no-repeat bottom center;
	text-decoration: none;
	padding: 10px 10px 2px;
}
#body_patients li#nav_patients a {
	color: #fff;
	background: #fff url(../img/nav_tabs_07.png) no-repeat bottom center;
	text-decoration: none;
	padding: 10px 10px 2px;
}
#body_moreinfo li#nav_moreinfo a {
	color: #fff;
	background: #fff url(../img/nav_tabs_09.png) no-repeat bottom center;
	text-decoration: none;
	padding: 10px 10px 2px;
}
#body_studycenters li#nav_studycenters a {
	color: #fff;
	background: #fff url(../img/nav_tabs_09.png) no-repeat bottom center;
	text-decoration: none;
	padding: 10px 10px 2px;
}
#body_resources li#nav_resources a {
	color: #fff;
	background: #fff url(../img/nav_tabs_09.png) no-repeat bottom center;
	text-decoration: none;
	padding: 10px 10px 2px;
}


/*** text styles ***/

h1, h3, h4 {
	color: #1d2b7d;
	font-family: Arial, Helvetica, sans-serif;
}
h1 {
	font-size: 1.7em;
	line-height: 1em;
	text-transform: uppercase;
	font-weight: normal;
}
h2 {
	color: #000;
	padding: 20px 0 10px;
	font: normal 1.2em Arial, Helvetica, sans-serif;
}
h3 {
	font-size: .8em;
	border-top: solid 1px #1d2b7d;
	border-bottom: solid 1px #d2d5e5;
	padding: 10px 0px;
	margin-bottom: 10px;
	line-height: 1.25em;
}
ul#main_nav li {
	display: inline;
	margin: 0 10px 0 0;
	font: bold .75em Arial, Helvetica, sans-serif;
	text-transform: uppercase;
}
div#content_main p, div#col_left p, div#moreinfo_form {
	padding: 8px 0;
	font-size: .7em;
	line-height: 1.35em;
	color: #333;
	/*color: #7f7f7f;*/
}
div#content_main p span.p_subhdr {
	color: #1d2b7d;
	font-weight: bold;
}
div#footer p {
	padding-top: 20px;
	line-height: 1.5;
	font-size: .65em;

}
div#footer p span.sm_links {
	display: block;
	width: 397px;
	float: right;
	text-align: right;
}
div#footer p span.sm_links a {
	padding-left: 30px;
}
div#content_box p.med_txt {
	font-size: .7em;
}
sup  {
	font-size: .6em;
	vertical-align: super;
}
div#content_main p.required {
    border-bottom: solid 1px #d2d5e5;
    padding-bottom: 20px;
}
div#content_main span.required_blue {
    color: #1d2b7d;
}


/*** get updates form ***/

div#col_left .getemail {
    border: solid 1px #ccc;
	width: 120px;
	height: 19px;
}
div#col_left .subscribe {
    border: none;
    border: solid 1px #ccc !important;
	background-color: #f4f5fe;
	padding: 2px 0;
	font: bold .7em Arial, Helvetica, sans-serif;
	color: #1d2b7d;
	width: 70px;
}
div#col_left span.error_txt {
    color: #ff0;
    font-size: .7em;
    line-height: 1.25em;
}
div#emailupdates_emailSubscribeArea div.thankyoutext {
    font-size: .7em;
    color: #1d2b7d;
}


/*** more info form ***/

div#moreinfo_form {
    width: 350px;
}
div#moreinfo_form input, div#moreinfo_form textarea, div#moreinfo_form select {
    margin: 3px 0 20px;
}
div#moreinfo_form td.text_info input {
    width: 95%
}
div#moreinfo_form td.select_info select {
    width: 97%
}
div#moreinfo_form td.multi_fields input {
    width: 90%;
}
div#moreinfo_form input#address1 {
    margin: 3px 0 5px;
}
div#moreinfo_form .signup {
    border: none;
    border: solid 1px #ccc !important;
	background-color: #f4f5fe;
	padding: 2px 0;
	font: bold .85em Arial, Helvetica, sans-serif;
	color: #1d2b7d;
	width: 70px;
}
div#moreinfo_form span.error_txt {
    color: #ff0;
    font-size: .85em;
    line-height: 1.25em;
}


/*** print styles ***/

@media print {

div#content_main p, 
div#col_left p, 
div#moreinfo_form   {
    color: #333;
    font-size: 11pt
}

}/*** end print styles ***/   

.blue-table {border: 1px solid #1a2880;padding-bottom:20px;}
.blue-table th{
	background:#1a2880 url(../img/bg-table-top.jpg) no-repeat;
	color:White;
	font-size: 110%;
	text-align: left;
	font-weight:normal;
	padding:20px 20px;
	height: 55px;
}
.blue-table td{color:#1a2880;padding:10px 20px 0;font-size: 90%;}
.blue-table a{color:#1a2880; text-decoration:underline;font-weight:bold; font-size:120%;}
.blue-table a.btn-click-here {
	width: 168px;
	text-indent: -999999px;
	display: block;
	height: 41px;
	background: url(../img/btn-click-here.jpg) no-repeat;
}


#ConfirmationMessage {position: relative; width: 500px; margin-bottom: 10px; display: block;}